This paper presents a case of a 53 year old, Filipino male, known to have Chronic Hepatitis B infection, presenting with bloatedness and unintentional weight loss attributed to a 21.3cm x 18.2cm x 16.6cm right liver mass with radiographic features pathognomonic for Hepatocellular Carcinoma. An incidental finding of a right renal mass measuring 3.5cm x 3.2cm x 3.4cm is seen in the inferoposterior pole was noted. Multidisciplinary team collectively decided to proceed with outright surgical resection of both hepatic and renal masses over preoperative biopsies of the masses. Histopathologic report of the Right Hemihepatectomy and Right Partial Nephrectomy confirmed the occurrence of a Double Primary Malignancy of Hepatocellular Carcinoma Stage IB and Renal Cell Carcinoma Stage I. The postoperative course is unremarkable, and given a locoregional disease, the patient will undergo active surveillance for tumor recurrence. To the best of the authors’ knowledge, this is the first case of double primary malignancy of the liver and kidney to be diagnosed and simultaneously resected in the Philippines. Improved prognosis of cancer patients and diagnostic modalities contributed to increasing number of reported cases with multiple primary malignancy. In the absence of a set standard of care, multidisciplinary approach has become of greater value in balancing the risks and benefits of selected timely interventions to the patients.
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