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Abstract
Background: The Gleason Sum derived from transrectal ultrasound guided prostate needle biopsy (TRUS-PNB) is critical in the selection of an appropriate treatment and also important in predicting the possible outcome. Scoring is therefore critical in the selection of a proper management. The concordance between prostate needle biopsy and radical prostatectomy histopathology in terms of the Gleason Sum was here in evaluated.
Methods: This is a retrospective cohort where a review and analysis of 28 charts were made. All patients who underwent TRUS-PNB and subsequently radical prostatectomy were included in the study. The concordance rates between prostate needle biopsy and radical prostatectomy histopathology were elucidated.
Results: With the Gleason Sum 6 upon TRUS-PNB (n=17), 9 (53.9%) matched their postoperative pathological findings, while 8 (47.0%) were upgraded to Gleason Sum 7. No finding of downgrading was observed postoperatively. Tumors graded GS7 on TRUS-PNB upon biopsy (n=11) had the best concordance; with 11 (100%) matched at radical prostatectomy. No over grading or downgrading was observed.
Conclusion: GS6 tumors being upgraded to GS7 tumors are still being observed. Owing the diagnosis of prostate cancer relying heavily on biopsy may still yield discordance. Though improvements with regards to biopsy technique may evolve, the usual 12 core biopsy is still being applied. With this, different factors that may predict discordance and strategies to minimize discordance still remain important for the appropriate treatment of prostate cancer.